Development of a Mass Flowmeter based on the Coriolis Acceleration for Liquid, Supercritical and Superfluid Helium

Beginning in the 1980's, Coriolis meters have gained generalised acceptance in liquid applications with a worldwide installed base of over 300,000 units. To meet the demands of cryogenic applications below 20 K, off-the-shelf Coriolis meters have been used, with minor design modifications and operational changes. The meters were originally calibrated on water and tested on liquid helium at 4.5 K, supercritical helium around 5 K and superfluid helium below 2 K. The meters maintain their intrinsic robustness and accuracy of better than 1% of measured value; accuracy is independent of density and temperature

Prediction of biopore- and matrix-dominated flow from X-ray CT-derived macropore network characteristics

Peer reviewedPublisher PD

Empirical foundations for the diagnosis of somatization:implications for DSM-5

Background. The aim of this study was to develop empirically validated criteria for the diagnoses of clinically relevant somatization. Method. This study was performed in a population-representative cohort consisting of 461 males (47.8%) and 503 females (52.2%), with an average age of 55.8 years (S.D. = 11.1). Somatization, anxiety and depression were derived from the Composite International Diagnostic Interview. Mplus was used to perform confirmative factor analyses on the current DSM-IV symptom groups; on alternative symptom clusters previously suggested; and to perform latent class analysis in order to define an empirically derived cut-off for somatization. Results. The existence of symptom groups as described in DSM-IV was not supported by our data, whereas a differentiation between cardiopulmonary, musculoskeletal, gastrointestinal and general somatic symptoms did fit our data. Latent class analysis revealed two classes characterized by few (n = 859) and many (n = 105) symptoms. The class of subjects could be approached by a simple cut-off of four functional symptoms (sensitivity 79%, specificity 98%, positive predictive value 82%, negative predictive value 97%) regardless of the number of organ systems involved. Conclusions. This study in a large population-representative cohort suggests that a simple symptom count can be used as a dimensional diagnosis of somatization. In those instances in which a categorical diagnosis is preferred, a simple cut-off of four out of 43 functional symptoms best fitted our data. We did not find any added value for incorporating the number of symptom clusters into the diagnostic criteria

Влияние стандартных схем противоязвенной терапии на клинико-лабораторные показатели у пациентов с язвенной болезнью двенадцатиперстной кишки

При изучении влияния стандартных схем квадритерапии второй линии на динамику клинико−лабораторных показателей у пациентов с язвенной болезнью двенадцатиперстной кишки установлено, что схемы с омепразолом, де−нолом, амоксициллином, тетрациклином и омепразолом, де−нолом, тетрациклином, метронидазолом одинаково влияют на динамику клинических симптомов и частоту эрадикации H. рylori. Однако первая схема более эффективно воздействует на нарушенные механизмы синтеза защитного слизистого барьера и процессы регенерации, что способствует более высокой частоте рубцевания язвы.При вивченні впливу стандартних схем квадрітерапії другої лінії на динаміку клініко−лабораторних показників у пацієнтів із виразковою хворобою дванадцятипалої кишки встановлено, що схеми з омепразолом, де−нолом, амоксициліном, тетрацикліном та омепразолом, де−нолом, тетрацикліном, метронідазолом однаково впливають на динаміку клінічних симптомів і частоту ерадикації H. рylori. Однак перша схема ефективніше впливає на порушені механізми синтезу захисного слизового бар'єру і процеси регенерації, що сприяє більш високій частоті рубцювання виразки.The investigation of the effect of standard schemes of second−line quadritherapy on the dynamics of clinical and laboratory parameters in patients with duodenal ulcer disease revealed that the scheme with Omeprazole, De−Nol, Amoxicillin, Tetracycline and Omeprazole De−Nol, Tetracycline, Metronidazole influence equally the dynamics of clinical symptoms and frequency of eradication of H. pylori. However, the first scheme more effectively influenced the disorders in the mechanism of synthesis of protective mucus barrier and regeneration processes, which contributed to the high frequency of ulcer cicatrisation

Fracture of the pancreas in two patients after a go‐kart accident

BackgroundAfter blunt abdominal trauma, an isolated injury to the pancreatic duct is uncommon. Physical signs and laboratory parameters are often inaccurate, and missing this diagnosis can cause serious clinical problems.Case outlinesTwo young women (aged 18 and 20 years) are reported who sustained isolated trauma to the pancreatic duct in go‐kart accidents. Each patient sustained a fracture of the pancreas. This injury was diagnosed only after a period of clinical observation with repeated laboratory parameters, ultrasound and CT scan. Pancreatic tissue was conserved by performing a pancreaticojejunostomy.DiscussionAfter any episode of blunt abdominal trauma, isolated injury to the pancreatic duct should be considered. Serum analysis, ultrasonography and CT scanning can be helpful in early diagnosis. Preservation of pancreatic tissue can be achieved with a good clinical outcome

Research Funding for Male Reproductive Health and Infertility in the UK and USA [2016 – 2019]

There is a paucity of data on research funding levels for male reproductive health (MRH). We investigated the research funding for MRH and infertility by examining publicly accessible web-databases from the UK and USA government funding agencies. Information on the funding was collected from the UKRI-GTR, the NIHR’s Open Data Summary, and the USA’s NIH RePORT web-databases. Funded projects between January 2016 and December 2019 were recorded and funding support was divided into three research categories: (i) male-based; (ii) female-based; and (iii) not-specified. Between January 2016 and December 2019, UK agencies awarded a total of £11,767,190 to 18 projects for male-based research and £29,850,945 to 40 projects for female-based research. There was no statistically significant difference in the median funding grant awarded within the male-based and female-based categories (p = 0.56, W = 392). The USA NIH funded 76 projects totalling $59,257,746 for male-based research and 99 projects totalling$83,272,898 for female-based research Again, there was no statistically significant difference in the median funding grant awarded between the two research categories (p = 0.83, W = 3834). This is the first study examining funding granted by main government research agencies from the UK and USA for MRH. This results should stimulate further discussion of the challenges of tackling male infertility and reproductive health disorders and formulating appropriate investment strategies.</p